By 2001, Stephen Sprouse, in collaboration with Marc Jacobs, designed a limited-edition line of Vuitton bags[10] that featured graffiti written over the monogram pattern. The graffiti read Louis Vuitton and, on certain bags, the name of the bag (such as Keepall and Speedy). Certain pieces, which featured the graffiti without the Monogram Canvas background, were only available on Louis Vuitton’s V.I.P. customer list. Jacobs also created the charm bracelet, the first-ever piece of jewellery from LV, within the same year.(Louis Vuitton Replica)

In 2002, the Tambour watch collection was introduced.[10] During this year, the LV building in Tokyo’s Ginza district was opened, and the brand collaborated with Bob Wilson for its Christmas windows scenography. In 2003, Takashi Murakami,[10] in collaboration with Marc Jacobs, masterminded the new Monogram Multicolore canvas range of handbags and accessories. This range included the monograms of the standard Monogram Canvas but in 33 different colours on either a white or black background. (The classic canvas features gold monograms on a brown background.) Murakami also created the Cherry Blossom pattern, in which smiling cartoon faces in the middle of pink and yellow flowers were sporadically placed atop the Monogram Canvas. This pattern appeared on a limited number of pieces. The production of this limited-edition run was discontinued in June 2003. Within 2003, the stores in Moscow, Russia, and in New Delhi, India were opened, the Utah and Suhali leather lines were released, and the 20th anniversary of the LV Cup was held.[10]

In 2004, Louis Vuitton celebrated its 150th anniversary. The brand also inaugurated stores in New York City (on Fifth Avenue), São Paulo, Mexico City, Cancun and Johannesburg. It also opened its first global store in Shanghai. By 2005, Louis Vuitton reopened its Champs-Élysées store in Paris designed by the American Architect Eric Carlson and released the Speedy watch collection. In 2006, LV held the inauguration of the Espace Louis Vuitton on its 7th floor.[10] In 2008, Louis Vuitton released the Damier Graphite canvas. The canvas features the classic Damier pattern but in black and grey, giving it a masculine look and urban feel. Also in 2008, Pharrell Williams co-designed a series of jewellery (“Blason”) and glasses for Louis Vuitton.[18]

In 2010, Louis Vuitton opened what is described as their most luxurious store in London.[19]

In early 2011, Louis Vuitton hired Kim Jones as its “Men Ready-to-Wear Studio and Style Director”. He became the lead designer of menswear while working under the company-wide artistic directorship of Marc Jacobs.[20]

On 17 September 2011, the company opened its Louis Vuitton Island Maison at Marina Bay Sands, Singapore.[21]